The “lnc” between 3D chromatin structure and X chromosome inactivation
Copyright policy )The “lnc” between 3D chromatin structure and X chromosome inactivation
The long non-coding RNA Xist directs a remarkable instance of developmentally regulated, epigenetic change known as X Chromosome Inactivation (XCI). By spreading in cis across the X chromosome from which it is expressed, Xist RNA facilitates the creation of a heritably silent, heterochromatic nuclear territory that displays a three-dimensional structure distinct from that of the active X chromosome. How Xist RNA attaches to and propagates across a chromosome and its influence over the three-dimensional (3D) structure of the inactive X are aspects of XCI that have remained largely unclear. Here, we discuss studies that have made significant contributions towards answering these open questions.
- University of California, Los Angeles United States
- UCLA Jonsson Comprehensive Cancer Center United States
- University of California United States
570, Chromosome conformation, 0601 Biochemistry and Cell Biology (for), 610, 3105 Genetics (for-2020), 1114 Paediatrics and Reproductive Medicine (for), Paediatrics and Reproductive Medicine, Genetic, Nuclear Proteins (mesh), X chromosome inactivation Xist, Models, X Chromosome Inactivation, Heterochromatin, Genetics, Animals (mesh), Long Noncoding (mesh), Animals, Humans, Non-coding RNA, 3101 Biochemistry and cell biology (for-2020), Developmental Biology (science-metrix), Humans (mesh), 31 Biological Sciences (for-2020), Chromatin (mesh), Models, Genetic, Genetics (rcdc), Human Genome, Generic health relevance (hrcs-hc), Nuclear Proteins, X Chromosome Inactivation (mesh), Biological Sciences, Human Genome (rcdc), Chromatin, Genetic (mesh), RNA, Long Noncoding, RNA, Long Noncoding, Generic health relevance, Biochemistry and Cell Biology, Developmental Biology
570, Chromosome conformation, 0601 Biochemistry and Cell Biology (for), 610, 3105 Genetics (for-2020), 1114 Paediatrics and Reproductive Medicine (for), Paediatrics and Reproductive Medicine, Genetic, Nuclear Proteins (mesh), X chromosome inactivation Xist, Models, X Chromosome Inactivation, Heterochromatin, Genetics, Animals (mesh), Long Noncoding (mesh), Animals, Humans, Non-coding RNA, 3101 Biochemistry and cell biology (for-2020), Developmental Biology (science-metrix), Humans (mesh), 31 Biological Sciences (for-2020), Chromatin (mesh), Models, Genetic, Genetics (rcdc), Human Genome, Generic health relevance (hrcs-hc), Nuclear Proteins, X Chromosome Inactivation (mesh), Biological Sciences, Human Genome (rcdc), Chromatin, Genetic (mesh), RNA, Long Noncoding, RNA, Long Noncoding, Generic health relevance, Biochemistry and Cell Biology, Developmental Biology
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