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Cell surface receptors in lysophospholipid signaling

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2004Publisher:Elsevier BVJournal:Seminars in Cell & Developmental Biology, volume 15, pages 457-465 (issn: 1084-9521,

Authors: Jerold Chun; Brigitte Anliker;

doi: 10.1016/j.semcdb.2004.05.005

pmid: 15271291

Cell surface receptors in lysophospholipid signaling

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Abstract

The lysophospholipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), regulate various signaling pathways within cells by binding to multiple G protein-coupled receptors. Receptor-mediated LPA and S1P signaling induces diverse cellular responses including proliferation, adhesion, migration, morphogenesis, differentiation and survival. This review will focus on major components of lysophospholipid signaling: metabolism, identification and expression of LPA and S1P receptors, general signaling pathways and specific signaling mechanisms in mouse embryonic fibroblasts. Finally, in vivo effects of LP receptor gene deletion in mice will be discussed.

Related Organizations

Scripps Research Institute
United States

Keywords

Mice, Receptors, Lysosphingolipid, Phenotype, Sphingosine, Animals, Lysophospholipids, Receptors, Lysophosphatidic Acid, Signal Transduction

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	195
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%