Retinal cell fate determination and bHLH factors
Copyright policy )Retinal cell fate determination and bHLH factors
Retinal development is controlled antagonistically by multiple basic helix-loop-helix (bHLH) transcriptional activators and repressors. bHLH repressors suppress bHLH activators and promote maintenance of progenitors and generation of glial cells. In contrast, bHLH activators override activities of bHLH repressors and promote neuronal differentiation. However, bHLH activators alone are not sufficient but homeodomain factors are additionally required for neuronal subtype specification. It is likely that homeodomain factors regulate the layer specificity but not the neuronal fate while bHLH activators determine the neuronal fate within the homedomain factor-specified layers. Thus, combinations of proper bHLH and homeodomain factors are required for neuronal subtype specification.
- Kyoto University Japan
Basic Helix-Loop-Helix Proteins, Homeodomain Proteins, Neurons, Retinal Ganglion Cells, Stem Cells, Helix-Loop-Helix Motifs, Gene Expression Regulation, Developmental, Cell Differentiation, Nerve Tissue Proteins, Models, Biological, Retina, DNA-Binding Proteins, Repressor Proteins, Amacrine Cells, Animals, Humans, Photoreceptor Cells, Neuroglia, Signal Transduction, Transcription Factors
Basic Helix-Loop-Helix Proteins, Homeodomain Proteins, Neurons, Retinal Ganglion Cells, Stem Cells, Helix-Loop-Helix Motifs, Gene Expression Regulation, Developmental, Cell Differentiation, Nerve Tissue Proteins, Models, Biological, Retina, DNA-Binding Proteins, Repressor Proteins, Amacrine Cells, Animals, Humans, Photoreceptor Cells, Neuroglia, Signal Transduction, Transcription Factors
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