SR-BI as a target of natural products and its significance in cancer
Copyright policy )SR-BI as a target of natural products and its significance in cancer
Scavenger receptor class B type I (SR-BI) protein is an integral membrane glycoprotein. SR-BI is emerging as a multifunctional protein, which regulates autophagy, efferocytosis, cell survival and inflammation. It is well known that SR-BI plays a critical role in lipoprotein metabolism by mediating cholesteryl esters selective uptake and the bi-directional flux of free cholesterol. Recently, SR-BI has also been identified as a potential marker for cancer diagnosis, prognosis, or even a treatment target. Natural products are a promising source for the discovery of new drug leads. Multiple natural products were identified to regulate SR-BI protein expression. There are still a number of challenges in modulating SR-BI expression in cancer and in using natural products for modulation of such protein expression. In this review, our purpose is to discuss the relationship between SR-BI protein and cancer, and the molecular mechanisms regulating SR-BI expression, as well as to provide an overview of natural products that regulate SR-BI expression.
- Shandong University of Traditional Chinese Medicine China (People's Republic of)
- University Hospital of Zurich Switzerland
- University of Zurich Switzerland
- Medical University of Vienna Austria
- Vanderbilt University Medical Center United States
SELECTIVE LIPID UPTAKE, CD36 Antigens, Cancer Research, Scavenger Receptors, 610 Medicine & health, 301204 Pharmakognosie, Scavenger receptor class B type I, SDG 3 - Good Health and Well-being, Neoplasms, Receptors, IMPROVES INSULIN SENSITIVITY, Humans, 1306 Cancer Research, 301204 Pharmacognosy, NITRIC-OXIDE SYNTHASE, Receptors, Immunologic, 610 Medicine & health, ELEMENT-BINDING PROTEIN-1A, Cancer, POLYUNSATURATED FATTY-ACIDS, Class B/metabolism, Natural products, Biological Products, REVERSE CHOLESTEROL TRANSPORT, APOLIPOPROTEIN-A-I, Biological Products/pharmacology, Molecular mechanisms, Scavenger Receptors, Class B, CD36 Antigens/metabolism, Immunologic/metabolism, Neoplasms/drug therapy, RECEPTOR-CLASS-B, TUMOR-ASSOCIATED MACROPHAGES, 10199 Clinic for Clinical Pharmacology and Toxicology, SDG 3 – Gesundheit und Wohlergehen, HIGH-DENSITY-LIPOPROTEIN
SELECTIVE LIPID UPTAKE, CD36 Antigens, Cancer Research, Scavenger Receptors, 610 Medicine & health, 301204 Pharmakognosie, Scavenger receptor class B type I, SDG 3 - Good Health and Well-being, Neoplasms, Receptors, IMPROVES INSULIN SENSITIVITY, Humans, 1306 Cancer Research, 301204 Pharmacognosy, NITRIC-OXIDE SYNTHASE, Receptors, Immunologic, 610 Medicine & health, ELEMENT-BINDING PROTEIN-1A, Cancer, POLYUNSATURATED FATTY-ACIDS, Class B/metabolism, Natural products, Biological Products, REVERSE CHOLESTEROL TRANSPORT, APOLIPOPROTEIN-A-I, Biological Products/pharmacology, Molecular mechanisms, Scavenger Receptors, Class B, CD36 Antigens/metabolism, Immunologic/metabolism, Neoplasms/drug therapy, RECEPTOR-CLASS-B, TUMOR-ASSOCIATED MACROPHAGES, 10199 Clinic for Clinical Pharmacology and Toxicology, SDG 3 – Gesundheit und Wohlergehen, HIGH-DENSITY-LIPOPROTEIN
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