The role of paraoxonase in cancer
Copyright policy )The role of paraoxonase in cancer
The paraoxonase (PON) gene family includes three proteins, PON1, PON2 and PON3. PON1 and PON3 are both associated with high-density lipoprotein (HDL) particles and exert anti-oxidant and anti-inflammatory properties. PON2 and PON3 are intracellular enzymes which modulate mitochondrial superoxide anion production and endoplasmic reticulum (ER) stress-induced apoptosis. The pleiotropic roles exerted by PONs have been mainly investigated in cardiovascular and neurodegenerative diseases. In recent years, overexpression of PON2 and PON3 has been observed in cancer cells and it has been proposed that both enzymes could be involved in tumor survival and stress resistance. Moreover, a lower activity of serum PON1 has been reported in cancer patients. This review summarizes literature data on the role of PONs in human cancers and their potential role as a target for antitumor drugs.
- Mashhad University of Medical Sciences Iran (Islamic Republic of)
- Biotechnology Research Center Iran (Islamic Republic of)
- Marche Polytechnic University Italy
Aryldialkylphosphatase, Apoptosis, Diet, Gene Expression Regulation, Neoplastic, Oxidative Stress, Risk Factors, Multigene Family, Neoplasms, Biomarkers, Tumor, Animals, Humans, Disease Susceptibility, Signal Transduction
Aryldialkylphosphatase, Apoptosis, Diet, Gene Expression Regulation, Neoplastic, Oxidative Stress, Risk Factors, Multigene Family, Neoplasms, Biomarkers, Tumor, Animals, Humans, Disease Susceptibility, Signal Transduction
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