Stem cells and cancer

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2007 English Publisher:Elsevier BVJournal:Seminars in Cancer Biology, volume 17, pages 191-203 (issn: 1044-579X,

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Authors: JeanMarie, Houghton; Alexei, Morozov; Iva, Smirnova; Timothy C, Wang;

doi: 10.1016/j.semcancer.2006.04.003

pmid: 16762563

Stem cells and cancer

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Abstract

The cell of origin of cancer has been a strongly debated topic through out the history of cancer research. This review provides a historic framework and a synopsis of how the theories of cancer initiation and progression evolved from early times to the present day. We present the concept of a cancer stem cell, and review for you the literature supporting the existence of cancer stem cells in addition to a brief discussion on our own work supporting a bone marrow-derived source for the cancer stem cell, as well as cells of the cancer stroma.

Related Organizations

Columbia University Medical Center
United States
University of Massachusetts Medical School
United States

Keywords

Neoplasms, Neoplastic Stem Cells, Animals, Humans

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