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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Resuscitationarrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Resuscitation
Article . 2017 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
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Recurrent out-of-hospital cardiac arrest

Authors: Stephen Bernard; Resmi Nair; Karen Smith; Ziad Nehme; Ziad Nehme; Emily Andrew;

Recurrent out-of-hospital cardiac arrest

Abstract

Little is known about the burden of recurrent out-of-hospital cardiac arrest (OHCA) episodes in initial survivors of OHCA. We sought to investigate the frequency of recurrent OHCA, describe time-to-event trends, and establish baseline predictors of occurrence.Between January 2000 and June 2015, we included consecutive OHCA survivors to hospital discharge from the Victorian Ambulance Cardiac Arrest Registry. Patient identifiers were used to match index and recurrent episodes of OHCA, and death records from a government database. Kaplan-Meier curves and a Cox proportional-hazards model were used to estimate the long-term risk of recurrent OHCA and identify index characteristics associated with their occurrence.Among 3581 survivors, 214 (6.0%) experienced a recurrent OHCA over a median time-at-risk of 5.0 years (interquartile range [IQR]: 2.0, 8.1). The median age at recurrent OHCA was 69 years, 72.9% were male, and 92.0% of events were fatal. Fatal recurrent OHCA episodes accounted for more than one-quarter of all deaths at follow-up. The probability of recurrent OHCA at 1, 5, 10 and 15 years was 2.4% (95% CI: 2.0%, 3.0%), 6.0% (95% CI: 5.2%, 6.9%), 8.4% (95% CI: 7.3%, 9.8%), and 11.2% (95% CI: 9.1%, 13.8%), respectively. In the multivariable model, the following baseline predictors were significantly associated with recurrent OHCA: respiratory (HR 1.88, 95% CI: 1.02, 3.47; p=0.045) or overdose/poisoning aetiology (HR 2.47, 95% CI: 1.08, 5.62; p=0.03), diabetes (HR 1.92, 95% CI: 1.17, 3.14, p=0.01), heart failure (HR 2.22, 95% CI: 1.28, 3.85; p=0.005), and renal insufficiency (HR 2.43, 95% CI: 1.23, 4.82; p=0.01). The risk of recurrent OHCA did not decline over the study period (per year increase: HR 0.97, 95% CI: 0.93, 1.01; p=0.13).Recurrent OHCA episodes occur frequently in OHCA survivors, and could account for as many as one-quarter of all deaths at follow-up. Index characteristics may help to identify at-risk patients.

Keywords

Male, Age Factors, Comorbidity, Kaplan-Meier Estimate, Middle Aged, Cardiopulmonary Resuscitation, Recurrence, Risk Factors, Humans, Female, Registries, Survivors, Out-of-Hospital Cardiac Arrest, Aged, Proportional Hazards Models, Retrospective Studies

  • BIP!
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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    19
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
19
Top 10%
Top 10%
Average
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