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Mismatch repair in Gram-positive bacteria

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2016 English Publisher:Elsevier BVJournal:Research in Microbiology, volume 167, pages 4-12 (issn: 0923-2508,

Authors: Justin S. Lenhart; Monica C. Pillon; Alba Guarné; Julie S. Biteen; Lyle A. Simmons;

doi: 10.1016/j.resmic.2015.08.006

pmid: 26343983

Mismatch repair in Gram-positive bacteria

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Abstract

DNA mismatch repair (MMR) is responsible for correcting errors formed during DNA replication. DNA polymerase errors include base mismatches and extra helical nucleotides referred to as insertion and deletion loops. In bacteria, MMR increases the fidelity of the chromosomal DNA replication pathway approximately 100-fold. MMR defects in bacteria reduce replication fidelity and have the potential to affect fitness. In mammals, MMR defects are characterized by an increase in mutation rate and by microsatellite instability. In this review, we discuss current advances in understanding how MMR functions in bacteria lacking the MutH and Dam methylase-dependent MMR pathway.

Related Organizations

University of Michigan–Flint
United States
McMaster University
Canada

Keywords

Adenosine Triphosphatases, DNA Replication, DNA, Bacterial, Bacillus, DNA-Directed DNA Polymerase, Gram-Positive Bacteria, DNA Mismatch Repair, MutS DNA Mismatch-Binding Protein, DNA-Binding Proteins, Bacterial Proteins, Mutation, Animals, Genetic Fitness

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	48
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%