The article by Cekirdekci and Bugan published in this issue of the Journal opens up new prospects for improving our knowledge of microvascular angina (MVA). Clinical characterization of MVA and coronary artery disease (CAD) shows them to be examples of endothelial dysfunction at the level of the microcirculation and macrocirculation, respectively. There is now general consensus about both coronary microcirculation and macrocirculation. The authors selected biomarkers of hemorheology and inflammation and applied clinical methodology to diagnose and classify the patients and the control group. The latter were similar to the MVA and CAD patient groups regarding the presence of other associated diseases. The statistical computation performed confirmed the value of the control group used, which in my opinion is more realistic than other control groups selected without comorbidities.

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