
pmid: 23337420
The concept that a bolus of gonadotrophin-releasing hormone agonist (GnRHa) can replace human chorionic gonadotrophin(HCG) as a trigger of final oocyte maturation was introduced several years ago. Recent developments in the area strengthen this premise. GnRHa trigger offers important advantages, including virtually complete prevention of ovarian hyperstimulation syndrome(OHSS), the introduction of a surge of FSH in addition to the LH surge and finally the possibility to individualize luteal-phase supplementation based on ovarian response to stimulation. We maintain that the automatic HCG triggering concept should be challenged and that the GnRHa trigger is the way to move forward with thoughtful consideration of the needs, safety and comfort of our patients.
Follicle Stimulating Hormone/blood, Luteal Phase, Chorionic Gonadotropin, Gonadotropin-Releasing Hormone, Ovarian Hyperstimulation Syndrome, FSH surge, Ovulation Induction, Reproductive Control Agents/administration & dosage, Risk Factors, Humans, Ovarian Hyperstimulation Syndrome/prevention & control, GnRH agonist, Gonadotropin-Releasing Hormone/agonists, LH surge, Oocytes/drug effects, Luteinizing Hormone, ovulation triggering, Ovulation Induction/methods, oocyte maturation, Luteal Phase/drug effects, OHSS, Chorionic Gonadotropin/administration & dosage, Oocytes, Luteinizing Hormone/blood, Reproductive Control Agents, Female, Follicle Stimulating Hormone
Follicle Stimulating Hormone/blood, Luteal Phase, Chorionic Gonadotropin, Gonadotropin-Releasing Hormone, Ovarian Hyperstimulation Syndrome, FSH surge, Ovulation Induction, Reproductive Control Agents/administration & dosage, Risk Factors, Humans, Ovarian Hyperstimulation Syndrome/prevention & control, GnRH agonist, Gonadotropin-Releasing Hormone/agonists, LH surge, Oocytes/drug effects, Luteinizing Hormone, ovulation triggering, Ovulation Induction/methods, oocyte maturation, Luteal Phase/drug effects, OHSS, Chorionic Gonadotropin/administration & dosage, Oocytes, Luteinizing Hormone/blood, Reproductive Control Agents, Female, Follicle Stimulating Hormone
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