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Reproductive BioMedicine Online
Article . 2013 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
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GnRH agonist triggering: recent developments

recent developments
Authors: Kol, Shahar; Humaidan, Peter; Al Humaidan, Peter Samir Heskjær; id_orcid 0000-0001-6884-5366;

GnRH agonist triggering: recent developments

Abstract

The concept that a bolus of gonadotrophin-releasing hormone agonist (GnRHa) can replace human chorionic gonadotrophin(HCG) as a trigger of final oocyte maturation was introduced several years ago. Recent developments in the area strengthen this premise. GnRHa trigger offers important advantages, including virtually complete prevention of ovarian hyperstimulation syndrome(OHSS), the introduction of a surge of FSH in addition to the LH surge and finally the possibility to individualize luteal-phase supplementation based on ovarian response to stimulation. We maintain that the automatic HCG triggering concept should be challenged and that the GnRHa trigger is the way to move forward with thoughtful consideration of the needs, safety and comfort of our patients.

Country
Denmark
Keywords

Follicle Stimulating Hormone/blood, Luteal Phase, Chorionic Gonadotropin, Gonadotropin-Releasing Hormone, Ovarian Hyperstimulation Syndrome, FSH surge, Ovulation Induction, Reproductive Control Agents/administration & dosage, Risk Factors, Humans, Ovarian Hyperstimulation Syndrome/prevention & control, GnRH agonist, Gonadotropin-Releasing Hormone/agonists, LH surge, Oocytes/drug effects, Luteinizing Hormone, ovulation triggering, Ovulation Induction/methods, oocyte maturation, Luteal Phase/drug effects, OHSS, Chorionic Gonadotropin/administration & dosage, Oocytes, Luteinizing Hormone/blood, Reproductive Control Agents, Female, Follicle Stimulating Hormone

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    popularity
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    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
83
Top 10%
Top 10%
Top 1%
bronze