Cross-species microRNA transmission modulates flavivirus growth in mosquitoes

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2022 English Publisher:Elsevier BVJournal:Trends in Parasitology, volume 38, pages 349-350 (issn: 1471-4922,

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Authors: Shwetha Shivaprasad; Peter Sarnow;

doi: 10.1016/j.pt.2022.02.007

pmid: 35246384

Cross-species microRNA transmission modulates flavivirus growth in mosquitoes

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Abstract

Mosquitoes can be infected with a variety of RNA viruses. Recently,Zhu et al. demonstrated that human microRNA hsa-miR-150-5p is acquired by mosquitoes during blood meals and protects the Dengue virus by downregulation of chymotrypsin AaCT-1 mRNA. This finding suggests the use of microRNA antagomirs as an antiviral approach in mosquitoes.

Related Organizations

Stanford University
United States

Keywords

MicroRNAs, Culicidae, Aedes, Flavivirus, Animals, Humans, Mosquito Vectors

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