Gastroesophageal reflux disease (GERD) is a prevalent disease caused by multiple facets of factors. Current Western Medicine treatment of GERD focuses mainly on symptom alleviation. Although proton-pump inhibitors are known to alleviate symptoms in most patients, a significant portion of patients continue to present GERD.Given multiple factors, including the involvement of psychosocial influences, that contribute to the pathogenesis of GERD, we sought to look beyond the current available treatments for a multitargeting therapy to combat this disease. Traditional Chinese Medicine, with a history of more than 2000 years, is known for its holistic approach in the treatment of human body.In this article, we aim to review the ancient Traditional Chinese Medicine literature and current Traditional Chinese Medicine studies related to GERD, thereby presenting the understanding of GERD from a TCM perspective.