Abstract One of the big challenges in fatigue characterization is to evaluate accumulated damage under asynchronous loading conditions. This multidisciplinary subject requires joining all multiaxial issues that are usually studied separately. Multiaxial fatigue models used in accumulated damage evaluation under random conditions are generally validated under loading blocks, which is a particular case of random loadings. In this work is evaluated the accumulated damage of asynchronous loading blocks using the stress scale factor (SSF) damage parameter, the virtual cycle counting, and a Palmgren–Miner type rule. Results show good agreement between the experimental data and the estimations.