O13. Microvascular and macrovascular hemodynamic effects of nicardipine in the treatment of severe pre-eclampsia

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2011 English Publisher:Elsevier BVJournal:Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, volume 1, page 263 (issn: 2210-7789,

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Authors: J, Cornette; J J, Duvekot; J W, Roos-Hesselink; E, Buijs; E, Herzog; Eric A P, Steegers;

doi: 10.1016/j.preghy.2011.08.045

pmid: 26009075

O13. Microvascular and macrovascular hemodynamic effects of nicardipine in the treatment of severe pre-eclampsia

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Abstract

(P = 0.008). aPWV was unaltered, even after adjustment for MAP (P = 0.6). Conclusion: This is the first study to investigate changes in AIx and PWV very early in pregnancy. We have demonstrated profound changes in brachial and central blood pressures and AIx within 2–3 weeks of conception, with no change in aPWV. Furthermore, late first trimester data cannot be used as ‘baseline’ data in order to identify the extent of cardiovascular adaptation in pregnancy as has been hitherto assumed.

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Erasmus University Rotterdam
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Erasmus University Medical Center
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