Alkaloids from Anacyclus pyrethrum
Copyright policy )Alkaloids from Anacyclus pyrethrum
Twelve undescribed alkaloids, including eight pyrrolo[3,2-g]isoquinoline alkaloids (+)/(-)-anacyquinoline A (1a/1b), (±)-anacyquinoline B (2), (+)/(-)-anacyquinoline C (3a/3b), (±)-anacyquinoline D (4), (±)-anacyquinoline E (5), and (±)-anacyquinoline F (6), together with four pyrrolo[2,3-g]quinoline alkaloids (+)/(-)-anacyquinoline G (7a/7b), (±)-anacyquinoline H (8), and (±)-anacyquinoline I (9), were isolated from the roots of Anacyclus pyrethrum (L.) DC. Their structures were determined via spectroscopic analyses (UV, IR, NMR), HRESIMS, quantum chemical calculations of ECD, DP4+ analysis, and single-crystal X-ray diffraction analysis (Cu Kα). Furthermore, in bioassay, (+)/(-)-anacyquinoline G (7a/7b) and (±)-anacyquinoline H (8) showed inhibition on nitric oxide production in lipopolysaccharide -induced RAW 264.7 cells with IC50 values of 41.4, 44.1, and 31.4 μM, respectively, indicating their potential anti-inflammatory bioactivity.
- University of Chinese Academy of Sciences China (People's Republic of)
- Xinjiang Medical University China (People's Republic of)
- Chinese Academy of Sciences China (People's Republic of)
Lipopolysaccharides, Mice, Structure-Activity Relationship, Alkaloids, RAW 264.7 Cells, Molecular Structure, Dose-Response Relationship, Drug, Quinolines, Anti-Inflammatory Agents, Animals, Asteraceae, Nitric Oxide, Plant Roots
Lipopolysaccharides, Mice, Structure-Activity Relationship, Alkaloids, RAW 264.7 Cells, Molecular Structure, Dose-Response Relationship, Drug, Quinolines, Anti-Inflammatory Agents, Animals, Asteraceae, Nitric Oxide, Plant Roots
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