Halimane and labdane diterpenoids from Leonurus japonicus and their anti-inflammatory activity

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2020 English Publisher:Elsevier BVJournal:Phytochemistry, volume 172, page 112,280 (issn: 0031-9422,

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Authors: Li, Hang-Ying; Li, Ya; Wei, Wen-Jun; Ma, Kai-Liang; Chen, Jian-Jun; Gao, Kun;

doi: 10.1016/j.phytochem.2020.112280

pmid: 32036185

Halimane and labdane diterpenoids from Leonurus japonicus and their anti-inflammatory activity

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Abstract

Ten highly oxygenated diterpenoids (nine undescribed ones) were isolated from the aerial parts of Leonurus japonicus Houtt. 14,15-Dinor-labd-5,8-dien-3,13-dione was a 14,15-dinor-labdane diterpenoid possessing a C18 skeleton. 7β,9α-Dihydroxy-6-oxo-labd-13-en-15,16-amide represented a rare example of labdane diterpenoid featuring an α,β-unsaturated-γ-lactam moiety. The structures of all compounds were elucidated using spectroscopic data analyses and comparisons. The effects of these obtained compounds on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW 264.7 cells were evaluated.(10R*,13R*,15R*)-15,16-Epoxy-6,13-dihydroxy-15-methoxy-labda-5,8-dien-7-one inhibited NO production with an IC50 value of 40.1 μM.

Related Organizations

State Key Laboratory of Applied Organic Chemistry
China (People's Republic of)
Lanzhou University
China (People's Republic of)

Keywords

Lipopolysaccharides, Mice, Leonurus, Molecular Structure, Anti-Inflammatory Agents, Animals, Biodiversity, Diterpenes, Taxonomy

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