Picraviane A and B: Nortriterpenes with limonoid-like skeletons containing a heptanolide E-ring system from Picramnia glazioviana
Copyright policy )Picraviane A and B: Nortriterpenes with limonoid-like skeletons containing a heptanolide E-ring system from Picramnia glazioviana
Two highly oxygenated nortriterpenes, picraviane A and B, were isolated from the ethanolic extract of Picramnia glazioviana Engl. The structures were determined by analysis of HRMS and 2D NMR spectroscopic data. Single-crystal X-ray diffraction data was also obtained for picraviane B. The absolute configuration of both compounds were assigned by comparison of experimental and calculated vibrational and electronic circular dichroism spectroscopy, respectively. Picraviane A showed a moderate cytotoxic activity against the triple negative MDA-MB-231 breast cancer cell line. These compounds represent an undescribed class of natural products with limonoid-like skeletons containing a heptanolide as the E-ring.
- UNIVERSIDADE DE SAO PAULO Brazil
- University of Copenhagen Denmark
- University of Copenhagen Denmark
- Universidade de São Paulo Brazil
- Federal University of São Carlos Brazil
Models, Molecular, Biological Products, Dose-Response Relationship, Drug, Cell Survival, Molecular Conformation, Stereoisomerism, Biodiversity, Antineoplastic Agents, Phytogenic, Triterpenes, Structure-Activity Relationship, Cell Line, Tumor, Simaroubaceae, Humans, Drug Screening Assays, Antitumor, Taxonomy, Cell Proliferation
Models, Molecular, Biological Products, Dose-Response Relationship, Drug, Cell Survival, Molecular Conformation, Stereoisomerism, Biodiversity, Antineoplastic Agents, Phytogenic, Triterpenes, Structure-Activity Relationship, Cell Line, Tumor, Simaroubaceae, Humans, Drug Screening Assays, Antitumor, Taxonomy, Cell Proliferation
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