Bisindole alkaloids from Tabernaemontana corymbosa
Copyright policy )Bisindole alkaloids from Tabernaemontana corymbosa
Continued study in bioactive monoterpenoid alkaloids led to the isolation of nine undescribed alkaloids, taberyunines A-I, together with 32 known ones from the aerial parts of Tabernaemontana corymbosa Roxb. ex Wall (Apocynaceae). Among the undescribed alkaloids, taberyunines A-G and H-I were assigned to Aspidosperma-Aspidosperma and Vobasinyl-Ibogan type bisindoles, respectively. Their structures were determined by NMR spectra, MS data and X-ray diffraction. Taberyunine B showed significant cytotoxicity against three cancer cell lines.
- Kunming Institute of Botany China (People's Republic of)
- Beijing University of Chinese Medicine China (People's Republic of)
- Chinese Academy of Sciences China (People's Republic of)
Dose-Response Relationship, Drug, Tabernaemontana, Tumor Necrosis Factor-alpha, NF-kappa B, Antineoplastic Agents, Phytogenic, Indole Alkaloids, Polymerization, Structure-Activity Relationship, HEK293 Cells, Tubulin, Cell Line, Tumor, Humans, Drug Screening Assays, Antitumor, Cell Proliferation, Signal Transduction
Dose-Response Relationship, Drug, Tabernaemontana, Tumor Necrosis Factor-alpha, NF-kappa B, Antineoplastic Agents, Phytogenic, Indole Alkaloids, Polymerization, Structure-Activity Relationship, HEK293 Cells, Tubulin, Cell Line, Tumor, Humans, Drug Screening Assays, Antitumor, Cell Proliferation, Signal Transduction
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