Biotransformation of cyclocanthogenol by the endophytic fungus Alternaria eureka 1E1BL1

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jul 2018 Turkey English Publisher:Elsevier BVJournal:Phytochemistry, volume 151, pages 91-98 (issn: 0031-9422,

Copyright policy )Funded by:TUBITAK | Astragalus Sikloartanları...

Authors: Ekiz, Guner; Duman, Seda; Bedir, Erdal;

doi: 10.1016/j.phytochem.2018.04.006

pmid: 29677643

Biotransformation of cyclocanthogenol by the endophytic fungus Alternaria eureka 1E1BL1

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Abstract

The microbial transformation of cyclocanthogenol (CCG), Astragalus sp. originated sapogenin, by the endophytic fungus Alternaria eureka 1E1BL1 isolated from Astragalus angustifolius was investigated. Hydroxylation, oxidation, epoxidation, O-methylation, ring-expansion and methyl migration reactions were observed on the triterpenoid skeleton. As a result, eight metabolites were isolated and the structures of the previously undescribed compounds were established by 1-D, 2-D NMR and HR-MS analyses.

Country

Turkey

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Keywords

Sapogenins, Astragalus, Molecular Conformation, Alternaria, Fabaceae, Stereoisomerism, Cycloartanes, Alternaria eureka, Cyclocanthogenol, Biotransformation, Endophytic fungus

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