Prenylated flavonoids from Commiphora opobalsamum stem bark

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2017 English Publisher:Elsevier BVJournal:Phytochemistry, volume 141, pages 80-85 (issn: 0031-9422,

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Authors: Ali A, El-Gamal; Shaza M, Al-Massarani; Wael M, Abdel-Mageed; Amina, El-Shaibany; Hassan M, Al-Mahbashi; Omer A, Basudan; Farid A, Badria; +2 Authors

doi: 10.1016/j.phytochem.2017.05.014

pmid: 28582635

Prenylated flavonoids from Commiphora opobalsamum stem bark

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Abstract

A phytochemical study on the stem bark of Commiphora opobalsamum looking for cytotoxic compounds afforded eleven flavonoids, including six previously undescribed prenylated congeners, comophorin A-E, and comophoroside A. The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. Isolated compounds were biologically evaluated using in vitro cytotoxicity MTT-based assay against two cancer cell lines; namely human hepato-cellular carcinoma (HepG-2) and human breast adenocarcinoma (MCF-7). Comophoroside A revealed to retain the strongest cytotoxic activity against MCF-7 and HepG-2 cell lines with IC50 values of 8 and 12 μg/mL, respectively.

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Keywords

Flavonoids, Prenylation, Molecular Structure, MCF-7 Cells, Plant Bark, Humans, Hep G2 Cells, Drug Screening Assays, Antitumor, Antineoplastic Agents, Phytogenic, Commiphora

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