Microbial metabolism of α-mangostin isolated from Garcinia mangostana L.
Copyright policy )Microbial metabolism of α-mangostin isolated from Garcinia mangostana L.
α-Mangostin (1), a prenylated xanthone isolated from the fruit hull of Garcinia mangostana L., was individually metabolized by two fungi, Colletotrichum gloeosporioides (EYL131) and Neosartorya spathulata (EYR042), repectively. Incubation of 1 with C. gloeosporioides (EYL131) gave four metabolites which were identified as mangostin 3-sulfate (2), mangostanin 6-sulfate (3), 17,18-dihydroxymangostanin 6-sulfate (4)and isomangostanin 3-sulfate (5). Compound 2 was also formed by incubation with N. spathulata (EYR042). The structures of the isolated compounds were elucidated by spectroscopic data analysis. Of the isolated metabolites, 2 exhibited significant anti-mycobacterial activity against Mycobacterium tuberculosis.
- Srinakharinwirot University Thailand
- Okayama University Japan
Molecular Structure, Xanthones, Stereoisomerism, Microbial Sensitivity Tests, Anti-Bacterial Agents, Garcinia mangostana
Molecular Structure, Xanthones, Stereoisomerism, Microbial Sensitivity Tests, Anti-Bacterial Agents, Garcinia mangostana
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