Steroidal saponins from Asparagus acutifolius

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2007 English Publisher:Elsevier BVJournal:Phytochemistry, volume 68, pages 2,554-2,562 (issn: 0031-9422,

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Authors: Marc, Sautour; Tomofumi, Miyamoto; Marie-Aleth, Lacaille-Dubois;

doi: 10.1016/j.phytochem.2007.02.033

pmid: 17449075

Steroidal saponins from Asparagus acutifolius

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Abstract

Six new steroidal saponins (1-6) were isolated from the roots of A. acutifolius L., together with a known spirostanol glycoside (7). Their structures were elucidated mainly by extensive spectroscopic analysis (1D and 2D NMR, FABMS and HRESIMS). Compounds 4-7 demonstrated antifungal activity against the human pathogenic yeasts C. albicans, C. glabrata and C. tropicalis with MICs values between 12.5 and 100 microg/ml.

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Keywords

Antifungal Agents, Steroids, Heterocyclic, Molecular Structure, Hydrolysis, Saponins, Asparagus Plant, Plant Roots, Candida

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