Isolation, identification and stability of acylated derivatives of apigenin 7-O-glucoside from chamomile (Chamomilla recutita [L.] Rauschert)
Copyright policy )Isolation, identification and stability of acylated derivatives of apigenin 7-O-glucoside from chamomile (Chamomilla recutita [L.] Rauschert)
The major flavonoids in the white florets of chamomile (Chamomilla recutita [L.] Rauschert) were rapidly purified using a combination of polyamide solid-phase extraction and preparative HPLC. From the combined LC/MS, LC/MS/MS, and NMR data the apigenin glucosides were identified as apigenin 7-O-glucoside (Ap-7-Glc), Ap-7-(6"-malonyl-Glc), Ap-7-(6"-acetyl-Glc), Ap-7-(6"-caffeoyl-Glc), Ap-7-(4"-acetyl-Glc), Ap-7-(4"-acetyl,6"-malonyl-Glc), and a partially characterised apigenin-7-(mono-acetyl/mono-malonylglucoside) isomer. Malonyl and caffeoyl derivatives of Ap-7-Glc have not previously been identified in chamomile. The two mono-acetyl/mono-malonyl flavonoids have not previously been reported in any plant species. These acylated glucosides are unstable and degrade to form acetylated compounds or Ap-7-Glc. The degradation products formed are dependent on the extraction and storage conditions, i.e. temperature, pH and solvent.
- Università degli studi di Salerno Italy
- University of East Anglia United Kingdom
- Norwich Research Park United Kingdom
- Quadram Institute United Kingdom
Magnetic Resonance Spectroscopy, Matricaria, Anti-Inflammatory Agents, Temperature, 610, Acetylation, Hydrogen-Ion Concentration, 540, Gas Chromatography-Mass Spectrometry, Biodegradation, Environmental, Drug Stability, Glucosides, Isomerism, Solvents, Apigenin, Asteraceae, Chamomilla recutita, LC/MS, NMR, Apigenin acyl-glucosides, Flavonoid stability, Chromatography, High Pressure Liquid
Magnetic Resonance Spectroscopy, Matricaria, Anti-Inflammatory Agents, Temperature, 610, Acetylation, Hydrogen-Ion Concentration, 540, Gas Chromatography-Mass Spectrometry, Biodegradation, Environmental, Drug Stability, Glucosides, Isomerism, Solvents, Apigenin, Asteraceae, Chamomilla recutita, LC/MS, NMR, Apigenin acyl-glucosides, Flavonoid stability, Chromatography, High Pressure Liquid
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