Thyroxine replacement in an animal model of congenital hypothyroidism
Copyright policy )Thyroxine replacement in an animal model of congenital hypothyroidism
This study examined the effects of thyroxine (T(4)) treatment on spatial learning and memory in congenitally hypothyroid (CH) rats. Forty CH male offspring of methimazole-treated dams were randomly divided into three groups: no T(4) (vehicle) treatment (n=12), T(4) treatment commencing on postnatal day (P-) 7 (n=14), and T(4) treatment commencing on P-21 (n=14). Normal male rats were used as a control group (n=14). T(4) was administered daily (sc, 0.02 microg/g) to the treatment groups for 30 days. A water-maze was used to assess behaviour at 42, 70 and 98 days of age. T(4) treatment beginning at P-7 improved learning and memory associated with CH at 70 and 98 days of age but T(4) treatment beginning at P-21 did not improve CH-impaired learning and memory.
- Queen's University Canada
- Queen's University Belfast United Kingdom
- University of Ulster United Kingdom
- Trinity College Dublin Ireland
Male, Thyroid Hormones, Hormone Replacement Therapy, Drug Administration Schedule, Discrimination Learning, Rats, Sprague-Dawley, Random Allocation, Pregnancy, /dk/atira/pure/subjectarea/asjc/2800/2802, Congenital Hypothyroidism, Animals, Maze Learning, Analysis of Variance, name=Physiology (medical), Methimazole, Critical Period, Psychological, Age Factors, /dk/atira/pure/subjectarea/asjc/2700/2737, Rats, Disease Models, Animal, Thyroxine, Space Perception, name=Behavioral Neuroscience, Female
Male, Thyroid Hormones, Hormone Replacement Therapy, Drug Administration Schedule, Discrimination Learning, Rats, Sprague-Dawley, Random Allocation, Pregnancy, /dk/atira/pure/subjectarea/asjc/2800/2802, Congenital Hypothyroidism, Animals, Maze Learning, Analysis of Variance, name=Physiology (medical), Methimazole, Critical Period, Psychological, Age Factors, /dk/atira/pure/subjectarea/asjc/2700/2737, Rats, Disease Models, Animal, Thyroxine, Space Perception, name=Behavioral Neuroscience, Female
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