Leptin signaling

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2004 English Publisher:Elsevier BVJournal:Physiology & Behavior, volume 81, pages 223-241 (issn: 0031-9384,

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Authors: Rexford S, Ahima; Suzette Y, Osei;

doi: 10.1016/j.physbeh.2004.02.014

pmid: 15159169

Leptin signaling

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Abstract

The discovery of leptin was a major breakthrough in our understanding of the role of adipose tissue as a storage and secretory organ. Leptin was initially thought to act mainly to prevent obesity; however, studies have demonstrated profound effects of leptin in the response to fasting, regulation of neuroendocrine and immune systems, hematopoiesis, bone and brain development. This review will focus on the signaling pathways which mediate these diverse effects of leptin in the brain and other physiologic systems.

Related Organizations

University of Pennsylvania
United States

Keywords

Leptin, Brain, Receptors, Cell Surface, Hormones, Mutation, Neural Pathways, Animals, Homeostasis, Humans, Receptors, Leptin, Energy Metabolism, Signal Transduction

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