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Physica A Statistical Mechanics and its Applications
Article
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arXiv.org e-Print Archive
Preprint . 2017
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Physica A Statistical Mechanics and its Applications
Article . 2017 . Peer-reviewed
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https://dx.doi.org/10.48550/ar...
Article . 2017
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Evolution of the ubiquitin-activating enzyme Uba1 (E1)

descriptionPublicationkeyboard_double_arrow_right Article , Preprint 01 Oct 2017Embargo end date: 01 Jan 2017 English Publisher:Elsevier BVJournal:Physica A: Statistical Mechanics and its Applications, volume 483, pages 456-461 (issn: 0378-4371, Copyright policy )
Authors: Allan, Douglas C.; Phillips, J. C.;

doi: 10.1016/j.physa.2017.04.144 , 10.48550/arxiv.1702.06950

arXiv: 1702.06950

Evolution of the ubiquitin-activating enzyme Uba1 (E1)

Abstract

Ubiquitin tags diseased proteins and initiates an enzyme conjugation cascade, which has three stages. The first-stage enzyme Uba1 (E1) has evolved only modestly from slime mold to humans, and is > 14 times larger than Ub. Here we use critical point thermodynamic scaling theory to connect Uba1 (E1) evolution from yeast and slime mold to fruit flies and humans to subtle changes in its amino acid sequences.

12 pages, 6 figures

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Keywords

FOS: Biological sciences, Other Quantitative Biology (q-bio.OT), Quantitative Biology - Other Quantitative Biology

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    selected citations
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 8
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
8
Top 10%
Average
Top 10%
Green
bronze