Tanshinone IIA and tanshinone I production by Trichoderma atroviride D16, an endophytic fungus in Salvia miltiorrhiza
Copyright policy )Tanshinone IIA and tanshinone I production by Trichoderma atroviride D16, an endophytic fungus in Salvia miltiorrhiza
In this study the isolation of an endophytic fungus from the root of the medicinal herb Salvia miltiorrhiza Bunge is reported for the first time. The fungus produced tanshinone I and tanshinone IIA in rich mycological medium (potato dextrose broth) under shake flask and bench scale fermentation conditions. The fungus was identified as Trichoderma atroviride by its morphology and authenticated by ITS analysis (ITS1 and ITS2 regions and the intervening 5.8S rDNA region). Tanshinone I and tanshinone IIA were identified by HPLC and LC-HRMS/MS and confirmed through comparison with authentic standards. This endophytic fungus has significant scientific and industrial potential to meet the pharmaceutical demands for tanshinone I and tanshinone IIA in a cost-effective, easily accessible and reproducible way.
- Changhai Hospital China (People's Republic of)
- Second Military Medical University China (People's Republic of)
- Liverpool John Moores University United Kingdom
Trichoderma, Mycelium, Methanol, Salvia miltiorrhiza, Plant Roots, Culture Media, RNA, Ribosomal, 5.8S, Abietanes, DNA, Ribosomal Spacer, Fermentation, Endophytes, DNA, Fungal, Chromatography, High Pressure Liquid, Drugs, Chinese Herbal
Trichoderma, Mycelium, Methanol, Salvia miltiorrhiza, Plant Roots, Culture Media, RNA, Ribosomal, 5.8S, Abietanes, DNA, Ribosomal Spacer, Fermentation, Endophytes, DNA, Fungal, Chromatography, High Pressure Liquid, Drugs, Chinese Herbal
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