Abstract Interference cancellation is expected to have significant importance for next-generation wireless communication systems due to various co-channel deployment scenarios and denser frequency reuse. In this study, an interference cancellation receiver that exploits the unique characteristics of single-carrier frequency-division multiple access based systems is proposed. The proposed receiver suppresses the co-channel dominant interference by blanking frequency-domain samples where the desired and interfering signals overlap. In order to improve the performance, demodulation and regeneration stages can be introduced and repeated multiple times. Further enhancement is possible by initially accommodating a group of reliable symbols before the iterations. The simulation results indicate that proposed methods work particularly well for low overlap ratios compared to interference coordination and no cancellation schemes.