Peripheral adrenomedullin inhibits gastric emptying through CGRP8–37-sensitive receptors and prostaglandins pathways in rats
Copyright policy )Peripheral adrenomedullin inhibits gastric emptying through CGRP8–37-sensitive receptors and prostaglandins pathways in rats
The effects of intravenous (iv) adrenomedullin (AM) on gastric emptying were investigated in conscious rats. AM induced a maximal 50% inhibition of gastric emptying at a dose of 1.2 nmol/kg. AM was about two-fold less potent than alpha-calcitonin gene-related peptide (alpha-CGRP), which induced a similar 50% maximal inhibition of gastric emptying at 0.6 nmol/kg. Delayed gastric emptying induced by i.v. AM and alpha-CGRP was prevented by peripheral injection of the selective CGRP1 antagonist, CGRP8-37, and by pretreatment with indomethacin, while not altered by blockade of the sympathetic nervous system with propranolol. These data indicate that peripheral AM inhibits gastric emptying through the interaction with CGRP8-37 -sensitive receptors, likely CGRP1 receptors, and the recruitment of prostaglandin-dependent mechanisms.
- University of California, Los Angeles United States
Male, Calcitonin Gene-Related Peptide, Indomethacin, Receptors, Calcitonin, Peptide Fragments, Rats, Rats, Sprague-Dawley, Adrenomedullin, Gastric Emptying, Receptors, Adrenergic, beta, Prostaglandins, Animals, Humans, Peptides, Receptors, Calcitonin Gene-Related Peptide
Male, Calcitonin Gene-Related Peptide, Indomethacin, Receptors, Calcitonin, Peptide Fragments, Rats, Rats, Sprague-Dawley, Adrenomedullin, Gastric Emptying, Receptors, Adrenergic, beta, Prostaglandins, Animals, Humans, Peptides, Receptors, Calcitonin Gene-Related Peptide
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