descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2011 English Publisher:Elsevier BVJournal:Progress in Biophysics and Molecular Biology, volume 106, pages 410-413 (issn: 0079-6107,

Authors: Stuart G, Baker; Barnett S, Kramer;

doi: 10.1016/j.pbiomolbio.2011.03.002

pmid: 21419159

pmc: PMC3156977

Systems biology and cancer: Promises and perils

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Abstract

Systems biology uses systems of mathematical rules and formulas to study complex biological phenomena. In cancer research there are three distinct threads in systems biology research: modeling biology or biophysics with the goal of establishing plausibility or obtaining insights, modeling based on statistics, bioinformatics, and reverse engineering with the goal of better characterizing the system, and modeling with the goal of clinical predictions. Using illustrative examples we discuss these threads in the context of cancer research.

Related Organizations

National Cancer Institute
United States

Keywords

Systems Biology, Computational Biology, Microarray Analysis, Models, Biological, Engineering, ROC Curve, Neoplasms, Animals, Humans

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