Applications of artificial intelligence (AI) and machine learning (ML) are rapidly developing to support the diagnosis and classification of pathology specimens. These tools rely on digitization of pathology glass slides as whole slide images, allowing computers to interpret image information. Tools to support the evaluation of pediatric pathology specimens have been slower to develop, in part because specimens that can be used to train these tools are less common. Here, we selectively highlight diagnostic and prognostic applications of AI and ML tools uniquely designed to support the evaluation of neoplastic and non-neoplastic pediatric pathology specimens.