Lysosomal exoglycosidases in nasal polyps
Copyright policy )Lysosomal exoglycosidases in nasal polyps
Nasal polyps are smooth outgrowths assuming a shape of grapes, formed from the nasal mucosa, limiting air flow by projecting into a lumen of a nasal cavity. Up to now the surgical resection is the best method of their treatment, but etiology and pathogenesis of the nasal polyps is not yet fully established.The aim of the study was the assessment of the selected lysosomal exoglycosidases activity in the nasal polyps. In this study the activity of β-galactosidase, α-mannosidase and α-fucosidase was determined in the tissue of the nasal polyps obtained from 40 patients (10F, 30M) and control tissues derived from mucosa of lower nasal conchas obtained during mucotomy from 20 patients (10F, 10M).We observed significant lower values of GAL, FUC and tendency to decrease of MAN and GLU concentration in nasal polyps (P) in comparison to control healthy nasal mucosa (C). In nasal polyp tissue (P) no differences of GAL, MAN and FUC specific activity in comparison to control mucosa (C) were found.Our research supports bioelectrical theory of the nasal polyps pathogenesis and directs attention at research on glycoconjugates and glycosidases of the nasal mucosa extracellular matrix.
Adult, Male, Nasal polyps - pathology, Lysosomes - enzymology, alpha-L-fucosidase - metabolism, Young Adult, Nasal Polyps, alpha-Mannosidase, 80 and over, Humans, Middle aged, beta-Galactosidase - metabolism, Aged, Aged, 80 and over, alpha-L-Fucosidase, Nasal mucosa - pathology, Middle Aged, beta-Galactosidase, Alpha-Mannosidase - metabolism, Extracellular Matrix, Nasal Mucosa, Young adult, Nasal polyps - enzymology, Extracellular matrix - enzymology, Nasal mucosa - enzymology, Female, Lysosomes
Adult, Male, Nasal polyps - pathology, Lysosomes - enzymology, alpha-L-fucosidase - metabolism, Young Adult, Nasal Polyps, alpha-Mannosidase, 80 and over, Humans, Middle aged, beta-Galactosidase - metabolism, Aged, Aged, 80 and over, alpha-L-Fucosidase, Nasal mucosa - pathology, Middle Aged, beta-Galactosidase, Alpha-Mannosidase - metabolism, Extracellular Matrix, Nasal Mucosa, Young adult, Nasal polyps - enzymology, Extracellular matrix - enzymology, Nasal mucosa - enzymology, Female, Lysosomes
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).3 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!