Mitomycin C Effect on Fibrous Adhesions of Rabbit Temporomandibular Joint
Copyright policy )Mitomycin C Effect on Fibrous Adhesions of Rabbit Temporomandibular Joint
OBJECTIVETo evaluate influence of mitomycin C on fibrosis in temporomandibular joints of rabbits with mandibular traction.STUDY DESIGNTwenty rabbits (8 control, 12 mitomycin C group) were included. Titanium screws were placed in the anterior edge of the right masseter tuberosity and the posterior part of the right zygoma. Elastic bands were placed between 2 screws to initiate posterio‐superior displacement of the mandible to the right. Animals in the control group (CG) received intraarticular NaCl (0.9%) on the nondrawing (left) side, and animals in the study group (SG) received mitomycin C weekly (0.4 mg/mL) for 6 weeks. Rabbits were decapitated, temporomandibular joints were removed, and histopathological investigation was performed.RESULTSMicroscopically, 4 of 6 rabbits in the CG had fibrosis in the temporomandibular joint, whereas only 1 of 11 rabbits in the SG had fibrosis (P < 0.05).CONCLUSIONApplication of mitomycin C to the temporomandibular joint of rabbits significantly reduces formation of intraarticular fibrous adhesions.SIGNIFICANCEThis is the first study in the literature investigating the use of mitomycin C in the joints.
- Başkent University Turkey
- Gazi University Turkey
Male, Dose-Response Relationship, Drug, Temporomandibular Joint, Mitomycin, Biopsy, Needle, Tissue Adhesions, Temporomandibular Joint Disorders, Fibrosis, Immunohistochemistry, Sensitivity and Specificity, Drug Administration Schedule, Injections, Intra-Articular, Disease Models, Animal, Random Allocation, Reference Values, Animals, Female, Rabbits, Probability
Male, Dose-Response Relationship, Drug, Temporomandibular Joint, Mitomycin, Biopsy, Needle, Tissue Adhesions, Temporomandibular Joint Disorders, Fibrosis, Immunohistochemistry, Sensitivity and Specificity, Drug Administration Schedule, Injections, Intra-Articular, Disease Models, Animal, Random Allocation, Reference Values, Animals, Female, Rabbits, Probability
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