The Pathophysiology of Cholesteatoma

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2006 English Publisher:Elsevier BVJournal:Otolaryngologic Clinics of North America, volume 39, pages 1,143-1,159 (issn: 0030-6665,

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Authors: Maroun T, Semaan; Cliff A, Megerian;

doi: 10.1016/j.otc.2006.08.003

pmid: 17097438

The Pathophysiology of Cholesteatoma

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Abstract

The pathogenesis of middle ear cholesteatoma continues to be highly debated. In recent years, there has been a substantial improvement in the understanding of the pathophysiology of this disease. This chapter provides a summary of the history and evolution of cholesteatoma and a review of the recent literature that pertains to the pathophysiology of congenital and acquired cholesteatoma. An emphasis is placed on the mechanism of osteolysis and the factors predictive of aggressiveness and recidivism.

Related Organizations

Case Western Reserve University
United States
University Hospitals of Cleveland
United States

Keywords

Cholesteatoma, Middle Ear, Humans, Otorhinolaryngologic Surgical Procedures

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