Myoepithelioma is a rare salivary gland neoplasm composed almost entirely of myoepithelial cells, with few ductal elements. The myoepithelial cells can be spindle, plasmacytoid, hyaline, or epithelioid and may also present a clear cytoplasm. This neoplasm occurs most often in the parotid gland and accounts for less than 7% of all cases of salivary gland tumors. A 75-year-old woman presented a painless tumor on the hard palate. The lesion was normochromic and had a smooth surface. The patient had been submitted to a previous incisional biopsy with a histopathologic diagnosis of myoepithelioma. After total excision of the lesion, the histopathologic examination showed a neoplasm composed of many spindle cells as well as some plasmacytoid and epithelioid cells on a myxomatous stroma. Rare ductal formations were noted. An immunohistochemical study was performed and showed positivity for S100, CK7, CK14, pan cytokeratin, smooth muscle actin , calponin, P63, and glial fibrillary acidic protein, confirming the diagnosis of myoepithelioma.