Parameters predicting complications in flap surgery

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2013 English Publisher:Elsevier BVJournal:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, volume 115, pages 589-594 (issn: 2212-4403,

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Authors: Jörg, Handschel; Stefan, Burghardt; Christian, Naujoks; Norbert R, Kübler; Günter, Giers;

doi: 10.1016/j.oooo.2012.09.007

pmid: 23246227

Parameters predicting complications in flap surgery

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Abstract

The aim of this prospective study was to determine laboratory parameters predicting complications and/or failure in flap surgery.Fifty-seven patients undergoing reconstructive surgery with cutaneous free and pedicled flaps were included. Blood samples were taken 2 days before surgery and 1, 3, 5, 7, and 14 days after. Parameters associated with thrombophilia, bleeding disorders, and wound healing were determined.In 45 (77%) of 57 patients no complications occurred. Bleeding (9%) and venous thrombosis of the flaps (9%) led in 18% of the cases to surgical revisions. Activated protein C resistance showed a significant (P < .05) cluster in cases with venous thrombosis, whereas it was absent in all other cases. Fibrinogen, factor VIII:C, von Willebrand factor (vWF) activity, and VWF antigen were significantly (P < .05) higher in patients with venous thrombosis compared with all other patients.Laboratory parameters of thrombosis and bleeding appear to be associated with complications in flap surgery.

Related Organizations

Heinrich Heine University Düsseldorf
Germany
University of Duesseldorf
Germany

Keywords

Male, Reoperation, Factor VIII, Hematologic Tests, Platelet Function Tests, Fibrinogen, Postoperative Hemorrhage, Plastic Surgery Procedures, Hemorrhagic Disorders, Free Tissue Flaps, Necrosis, C-Reactive Protein, Postoperative Complications, Humans, Female, Blood Coagulation Tests, Prospective Studies, Activated Protein C Resistance, Follow-Up Studies, Forecasting

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