The clinical potential of multidetector CT is significantly increased because of the possibility of almost instantaneous isotropic reformations in all planes, increased speed and coverage, and easy interpretation. Multidetector CT has a significant role in the correct and quick diagnosis and treatment of emergency department patients. In complex anatomic regions, it is an important diagnostic aid, and it allows exact classification of the bony lesion, which is important for diagnosis, treatment, and prognosis. Multidetector CT visualizes congenital deformities and is useful in oncology. Ongoing developments comprise diagnosis and treatment, preoperative and postoperative planning, and hard-ware imaging. Relatively new but well-known applications of multidetector CT include intraoperative navigation, implant and prosthesis planning and surgery simulation, vertebroplasty, and pedicle screw installations.