
pmid: 19467352
pmc: PMC2739591
The concept of reserve has been proposed to account for the disjunction between the degree of brain damage and its clinical outcome. This paper attempts to produce a coherent theoretical account the reserve in general and of cognitive reserve in particular. It reviews epidemiologic data supporting the concept of cognitive reserve, with a particular focus of its implications for aging and dementia. It then focuses on methodologic issues that are important when attempting to elucidate the neural underpinnings of cognitive reserve using imaging studies, and reviews some of our group's work in order to demonstrate these issues.
Adult, Aged, 80 and over, Brain Mapping, Aging, 330, 150, Age Factors, Brain, Brain--Magnetic resonance imaging, Middle Aged, Neuropsychological Tests, Magnetic Resonance Imaging, Young Adult, Cognition, Neuropsychology, Humans, Dementia, Aged
Adult, Aged, 80 and over, Brain Mapping, Aging, 330, 150, Age Factors, Brain, Brain--Magnetic resonance imaging, Middle Aged, Neuropsychological Tests, Magnetic Resonance Imaging, Young Adult, Cognition, Neuropsychology, Humans, Dementia, Aged
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