Greasing the Wheels of Regeneration

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2020 English Publisher:Elsevier BVJournal:Neuron, volume 105, pages 207-209 (issn: 0896-6273,

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Authors: Rafi, Kohen; Roman J, Giger;

doi: 10.1016/j.neuron.2019.11.032

pmid: 31972142

Greasing the Wheels of Regeneration

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Abstract

In this issue of Neuron, Yang et al. (2020) identify glycerolipid metabolism as a neuron-intrinsic mechanism that regulates axonal growth and regeneration. Shifting glycerolipid metabolism toward increased triglyceride synthesis blocks PNS neuron regeneration, whereas shifting it toward membrane phospholipid synthesis overcomes regeneration failure in CNS neurons.

Related Organizations

University of Michigan–Ann Arbor
United States
University of Michigan–Flint
United States

Keywords

Neurons, Axons, Nerve Regeneration

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