The Two Sides of NaV1.7: Painful and Painless Channelopathies

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2019 English Publisher:Elsevier BVJournal:Neuron, volume 101, pages 765-767 (issn: 0896-6273,

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Authors: Stephen G, Waxman; Sulayman D, Dib-Hajj;

doi: 10.1016/j.neuron.2019.02.016

pmid: 30844393

The Two Sides of NaV1.7: Painful and Painless Channelopathies

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Abstract

Sodium channel NaV1.7 is a major target in pain research, largely because of genetic validation. In this issue of Neuron, McDermott et al. (2019) now present a comprehensive assessment of congenital pain insensitivity due to NaV1.7 loss of function. This work and studies on NaV1.7 gain of function raise important questions about how channelopathies produce disease.

Related Organizations

VA Connecticut Healthcare System
United States
Yale University
United States

Keywords

Nociception, Humans, Pain, Channelopathies, Sodium Channels

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