Overcoming Depression by Inhibition of Neural Burst Firing

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2018 English Publisher:Elsevier BVJournal:Neuron, volume 98, pages 878-879 (issn: 0896-6273,

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Authors: Daesoo, Kim; Eunji, Cheong; Hee-Sup, Shin;

doi: 10.1016/j.neuron.2018.05.032

pmid: 29879390

Overcoming Depression by Inhibition of Neural Burst Firing

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Abstract

The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine has been found to have rapid and long-lasting antidepressive effects. Two elegant studies from Hailan Hu's laboratory (Cui et al., 2018; Yang et al., 2018) showed that ketamine blocks burst firing of neurons in the lateral habenula (LHb), rapidly relieving symptoms of depression.

Related Organizations

Yonsei University
Korea (Republic of)
Korean Association Of Science and Technology Studies
Korea (Republic of)
Institute for Basic Science
Korea (Republic of)
KAIST

Keywords

Neurons, Restraint, Physical, Depressive Disorder, Habenula, Anhedonia, Behavior, Animal, Receptors, N-Methyl-D-Aspartate, Rats, Calcium Channels, T-Type, Disease Models, Animal, Helplessness, Learned, Kcnj10 Channel, Animals, Ketamine, Potassium Channels, Inwardly Rectifying, Excitatory Amino Acid Antagonists

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