
pmid: 28384473
In this issue of Neuron, Ishiguro et al. (2017) explore the toxicity of RAN translation in spinocerebellar ataxia 31. Using a Drosophila model, the authors demonstrate that TDP-43 and other RNA-binding proteins act as chaperones to regulate the formation of toxic RNA aggregates.
DNA-Binding Proteins, Animals, RNA, RNA-Binding Proteins, Spinocerebellar Ataxias, Drosophila
DNA-Binding Proteins, Animals, RNA, RNA-Binding Proteins, Spinocerebellar Ataxias, Drosophila
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