Tau Propagation, Different Tau Phenotypes, and Prion-like Properties of Tau

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2014 English Publisher:Elsevier BVJournal:Neuron, volume 82, pages 1,189-1,190 (issn: 0896-6273,

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Authors: Hyman, Bradley T.;

doi: 10.1016/j.neuron.2014.06.004

pmid: 24945760

Tau Propagation, Different Tau Phenotypes, and Prion-like Properties of Tau

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Abstract

Sanders et al. (2014) demonstrate in this issue of Neuron that the natively unfolded protein tau can propagate indefinitely in distinct stable strains, therefore supporting the general idea that tau has prion-like properties, with implications for Alzheimer's disease and other tauopathies.

Related Organizations

Massachusetts General Hospital
United States
Harvard University
United States

Keywords

Tauopathies, Prions, Neuroscience(all), Animals, Humans, Neurodegenerative Diseases, tau Proteins, Hippocampus

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