Live or Let Die: CCM2 Provides the Link
Copyright policy )Live or Let Die: CCM2 Provides the Link
TrkA receptors are well known for promoting neuronal cell survival. However, in some neuroblastic tumors, TrkA activation can instead induce apoptosis. In this issue of Neuron, Harel et al. identify CCM2 as a mediator of TrkA-dependent cell death, suggesting that CCM2 is a distinctive type of tumor suppressor that modulates tyrosine kinase signaling.
- Dana-Farber Cancer Institute United States
- Harvard University United States
Cell Survival, Neuroscience(all), Membrane Proteins, Apoptosis, Neuroblastoma, Proto-Oncogene Proteins, Mutation, Humans, Receptor, trkB, Receptor, trkC, Receptor, trkA, Apoptosis Regulatory Proteins, Carrier Proteins, KRIT1 Protein, Microtubule-Associated Proteins, Medulloblastoma
Cell Survival, Neuroscience(all), Membrane Proteins, Apoptosis, Neuroblastoma, Proto-Oncogene Proteins, Mutation, Humans, Receptor, trkB, Receptor, trkC, Receptor, trkA, Apoptosis Regulatory Proteins, Carrier Proteins, KRIT1 Protein, Microtubule-Associated Proteins, Medulloblastoma
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