
pmid: 18093515
Synaptojanin1 degrades the signaling lipid phosphatidylinositol-4,5-bisphosphate and facilitates compensatory endocytosis, clathrin-coat disassembly, and vesicle reavailability at active synapses. In this issue of Neuron, Mani et al. provide new information about the separate roles of synaptojanin's two phosphatase domains and its interactions with endophilin in regulating these important aspects of the vesicle cycle.
Neuroscience(all), Mutation, Animals, Nerve Tissue Proteins, Synaptic Vesicles, Models, Biological, Acyltransferases, Clathrin, Endocytosis, Phosphoric Monoester Hydrolases
Neuroscience(all), Mutation, Animals, Nerve Tissue Proteins, Synaptic Vesicles, Models, Biological, Acyltransferases, Clathrin, Endocytosis, Phosphoric Monoester Hydrolases
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