Melanopsin: Another Way of Signaling Light
Copyright policy )Melanopsin: Another Way of Signaling Light
A subset of melanopsin-expressing retinal ganglion cells has been identified to be directly photosensitive (pRGCs), modulating a range of behavioral and physiological responses to light. Recent expression studies of melanopsin have provided compelling evidence that melanopsin is the photopigment of the pRGCs. However, the mechanism by which melanopsin transduces light information remains an open question. This review discusses the signaling pathways that may underlie melanopsin-dependent phototransduction in native pRGCs, as well as the many exciting challenges ahead.
- Imperial College London United Kingdom
- Charing Cross Hospital United Kingdom
- Imperial College Healthcare NHS Trust United Kingdom
Retinal Ganglion Cells, Light Signal Transduction, Light, Neuroscience(all), Rod Opsins, Animals, Humans, Melanopsin, Models, Biological, Signal Transduction
Retinal Ganglion Cells, Light Signal Transduction, Light, Neuroscience(all), Rod Opsins, Animals, Humans, Melanopsin, Models, Biological, Signal Transduction
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