Strong Single-Fiber Sensory Inputs to Olfactory Cortex: Implications for Olfactory Coding
Copyright policy )Strong Single-Fiber Sensory Inputs to Olfactory Cortex: Implications for Olfactory Coding
Olfactory information is first encoded in a combinatorial fashion by olfactory bulb glomeruli, which individually represent distinct chemical features of odors. This information is then transmitted to piriform (olfactory) cortex, via axons of olfactory bulb mitral and tufted (M/T) cells, where it is presumed to form the odor percept. However, mechanisms governing the integration of sensory information in mammalian olfactory cortex are unclear. Here we show that single M/T cells can make powerful connections with cortical pyramidal cells, and coincident input from few M/T cells is sufficient to elicit spike output. These findings suggest that odor coding is broad and distributed in olfactory cortex.
- UNIVERSITY OF CALIFORNIA SAN DIEGO
- Columbia University United States
- Columbia University United States
- University of California, San Diego United States
- UNIVERSITY OF CALIFORNIA, SAN DIEGO
Cerebral Cortex, Patch-Clamp Techniques, Neuroscience(all), Pyramidal Cells, Action Potentials, Excitatory Postsynaptic Potentials, Dose-Response Relationship, Radiation, Olfactory Pathways, In Vitro Techniques, MOLNEURO, Electric Stimulation, Olfactory Receptor Neurons, Rats, GABA Antagonists, Nerve Fibers, Animals, Newborn, Olfactory Mucosa, Odorants, Reaction Time, Animals, Picrotoxin, Anesthetics, Local
Cerebral Cortex, Patch-Clamp Techniques, Neuroscience(all), Pyramidal Cells, Action Potentials, Excitatory Postsynaptic Potentials, Dose-Response Relationship, Radiation, Olfactory Pathways, In Vitro Techniques, MOLNEURO, Electric Stimulation, Olfactory Receptor Neurons, Rats, GABA Antagonists, Nerve Fibers, Animals, Newborn, Olfactory Mucosa, Odorants, Reaction Time, Animals, Picrotoxin, Anesthetics, Local
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