3D QSAR models for α2a-adrenoceptor agonists☆
Copyright policy )3D QSAR models for α2a-adrenoceptor agonists☆
Three-dimensional structure-activity relationship studies of alpha2a-adrenoceptor agonists were carried out by Distance Comparison (DISCOthech) and Comparative Molecular Field Analysis (CoMFA) methods to define the pharmacophore and a quantitative model, respectively, of this class of compounds. The statistical validation of the CoMFA model indicates its high predictive performance for binding affinities of new alpha2a-adrenoceptor agonists.
- Semmelweis University Hungary
- University of Szeged Hungary
Models, Molecular, Receptors, Adrenergic, alpha-2, Adrenergic alpha-2 Receptor Agonists, Molecular Conformation, Quantitative Structure-Activity Relationship, Reproducibility of Results, Ligands, Adrenergic alpha-Agonists, Algorithms
Models, Molecular, Receptors, Adrenergic, alpha-2, Adrenergic alpha-2 Receptor Agonists, Molecular Conformation, Quantitative Structure-Activity Relationship, Reproducibility of Results, Ligands, Adrenergic alpha-Agonists, Algorithms
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