Statistical correlations are linear noninteractive relationships, but the dynamics of causation are nonlinear and involve complex interactions where variables change through their effect on one another and interact with the context of the patient over time. The discovery and interpretation of plaque vulnerable features in the individual patient are not determined for the asymptomatic patient being considered for carotid endarterectomy. New technologies for identification of plaque chemical and morphologic composition are on the horizon and may be applicable to certain patients but change in their usefulness as the plaque and patient change over time.