Recent advances in neuroimmunology have led to improvements in the pathogenesis, diagnosis, prognosis, and treatment of many neuromuscular disorders. The value of autoantibody testing is increasing steadily in neurologic practice. Not all antibodies have a high yield in diagnosis. In some disorders, such as generalized adult onset of myasthenia gravis, Lambert-Eaton myasthenic syndrome,Miller Fisher syndrome, and multifocal motor neuropathy,autoantibody tests provide accurate diagnosis and can be considered biologic markers of these disorders.